Laboratory of Antiviral Protection
COMPOSITION OF THE LABORATORY
The head of the laboratory is Bogoyavlensky Andrey Pavlinovich, Doctor of Biological Sciences, Professor, Academician of the Russian Academy of Sciences, Scopus ID 24281017300.
Laboratory staff:
The head of the laboratory is Bogoyavlensky Andrey Pavlinovich, Doctor of Biological Sciences, Professor, Academician of the Russian Academy of Sciences, Scopus ID 24281017300.
Laboratory staff:
- Kenzina Aizhan Sabirzhanovna, PhD, Chief Researcher;
- Aleksyuk Madina Saparbayeva, PhD, Leading Researcher;
- Zaitseva Irina Alekseevna, Researcher;
- Sokolova Nadezhda Sergeevna, Master of Biology, Researcher;
- Moldakhanov Yergali Slamidinovich, Master of Veterinary Medicine, Researcher;
- Anarkulova Elmira Izbasarovna, Master of Biology, Researcher;
- Akanova Kuralai Sailauovna, Master of Veterinary Medicine, Junior Researcher;
- Bolatova Bayan Bolatovna, Master of Engineering and Technology, laboratory assistant.
- Development of test systems for the diagnosis of viral infections using enzyme immunoassay and PCR diagnostics;
- Molecular and phylogenetic analysis, genetic mapping of viruses;
- Study of viral infection blocking mechanisms and development of new antiviral drugs;
- Study of biodiversity, distribution and ecology of viruses of various reservoirs of the Republic of Kazakhstan;
- Isolation of lytic bacteriophages, study of their properties and creation of new antibacterial drugs based on them.
- AP08052089 "Lytic bacteriophages against chicken escherichiosis as the basis of new therapeutic drugs"
- AP08855630 "Comparative analysis of antiviral activity of biologically active compounds isolated from mycelial extracts of xylophytic basidial fungi for the development of new pharmacological antiviral drugs"
- AP09058580 "Comparative study of the Caspian Sea virom as an important component of biodiversity conservation and biosafety of Kazakhstan"
- setting up PCR;
- sequencing;
- setting up an ELISA for the determination of virus antigens or antibodies to them.
- Alexyuk M.S., Turmagambetova A.S., Alexyuk P.G., Bogoyavlenskiy A.P., Berezin V.E. Comparative study of viromes from freshwater samples of the Ile-Balkhash region of Kazakhstan captured through metagenomic analysis // Virus Disease. – 2017. - V. 28, No1. - P. 18-25. DOI: 10.1007/s13337-016-0353-5.
- Bogoyavlenskiy A.P. Strategy of Control and Containment of Viral and other Infectious Diseases // J. Hum. Virol. Retrovirol. - 2017. - V.5, No 2. - P. 00150. DOI: 10.15406/jhvrv.2017.05.00150.
- Turmagambetova A.S., Alexyuk M.S., Bogoyavlenskiy A.P., Linster M., Alexyuk P.G., Zaitceva I.A., Smith G.J.D., Berezin V.E. Monitoring of Newcastle disease virus in environmental samples // Archives of Virology. - 2017. DOI: 10.1007/s00705-017-3433-y.
- Turmagambetova A.S., Alexyuk M.S., Alexyuk P.G., Bogoyavlenskiy A.P., Berezin V.E. Metagenomic analysis of NDV matrix protein gene from environmental samples // Acta Naturae. – 2017. – Special issue №1. – V. 9. – P. 43.
- Alexyuk M.S., Alexyuk P.G., Turmagambetova A.S., Bogoyavlenskiy A.P., Berezin V.E. Diversity of viral metabolic psb A gene in lake Balkhash // Acta Naturae. – 2017. – Special issue №1. – V. 9. – P. 42.
- Turmagambetova A.S., Alexyuk P.G., Bogoyavlenskiy A.P., Zaitseva I.A., Omirtaeva E.S., Alexyuk M.S., Sokolova N.S., Berezin V.E. Adjuvant activity of saponins from Kazakhstani plants on the immune responses to subunit influenza vaccine // Archives of Virology. - 2017. – Vol. 162, No 12. – P. 3817-3826. DOI: 10.1007/s00705-017-3560-5.
- Alexyuk P. G., Bogoyavlenskiy A. P., Alexyuk M. S., Turmagambetova A. S., Zaitseva I. A., Omirtaeva· E. S., Berezin V. E. Adjuvant activity of multimolecular complexes based on Glycyrrhiza glabra saponins, lipids, and influenza virus glycoproteins// Archives of Virology. -2019. - Vol. 164, No7.- P. 1793–1803, DOI: 10.1007/s00705-019-04273-2
- Moldakhanov YS, Alexyuk MS, Bogoyavlenskiy AP, Alexyuk PG, Turmagambetova AS, Zaitseva IA, Sokolova NS, Akanova KS, Anarkulova EI, Omirtaeva ES, Berezin VE. Complete genome sequence of Escherichia-infecting phage CEC_KAZ_2018, isolated from soil // Microbiol Resour Announc.- 2019. - 8:e00540-19. DOI: 10.1128/MRA .00540-19.
- Berezin V., Abdukhakimova D., Trenozhnikova L., Bogoyavlenskiy A., Turmagambetova A., Issanov, A., Azizan A., Antiviral activities of extremophilic actin1omycetes extracts from Kazakhstan's unique ecosystems against influenza viruses and paramyxoviruses // Virol J. – 2019. – Vol. 16, No 1. – P. 150. DOI: 10.1186/s12985-019-1254-1
- Alexyuk M., Bogoyavlenskiy A., Alexyuk P., Moldakhanov Y., Turmagambetova A., Anarkulova E., Berezin V. Complete Genome Sequence of vB_EcoP_PR_Kaz2018, a T7-Like Bacteriophage // Microbiol Resour Announc. - 2019. - 8:e01323-19. DOI: 10.1128/MRA.01323-19
- Turmagambetova A.S., Alexyuk M.S., Bogoyavlenskiy A.P., Alexyuk P.G., Zaitseva I.A., Omirtaeva E.S., Sokolova N.S., Berezin V.E. Effect of the nanocapsulated adjuvant Sapomax on the expression of some immune response genes // Archives of Virology. -2020. – Vol. 165. – P. 1445–1451. https://doi.org/10.1007/s00705-020-04619-1
- Alexyuk M.S., Bogoyavlenskiy A.P., Alexyuk P.G., Moldakhanov Y.S., Berezin V.E. Metagenome Analysis of Surface Waters of the Shardara Reservoir, the Largest Artificial Reservoir in Southern Kazakhstan // Microbiol Resour Announc. – 2020. – Vol. 9, No 11. -:e00053-20. DOI: 10.1128/MRA.00053-20.
- Alexyuk M., Bogoyavlenskiy A., Alexyuk P., Moldakhanov Y., Berezin V., Digel I. Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity // MicrobiologyOpen – 2020. — Vol. 10,N1. - e1142. DOI: 10.1002/mbo3.1142
- Alexyuk M., Bogoyavlenskiy A., Alexyuk P., Moldakhanov Y., Berezin V., Digel I. Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity // MicrobiologyOpen – 2020. — Vol. 10,N1. - e1142. DOI: 10.1002/mbo3.1142
- Bogoyavlensky A.P., Turmagambetova A.S., Berezin V.E., Aleksyuk M.S., Aleksyuk P.G. A set of degenerate oligonucleotides-primers for metagenomic studies. Patent of the Republic of Kazakhstan for invention No. 33403 dated 17.01.2019.
- Bogoyavlensky A.P., Aleksyuk M.S., Aleksyuk P.G., Turmagambetova A.S., Berezin V.E. A set of primers for detecting viruses in aqueous samples by polymerase chain reaction. Patent of the Republic of Kazakhstan for invention No. 33410 dated 21.01.2019.
- Bogoyavlensky A.P., Turmagambetova A.S., Berezin V.E., Aleksyuk M.S., Aleksyuk P.G., Zaitseva I.A., Omirtaeva E.S. Phytocomposition for the prevention and therapy of influenza. Patent of the Republic of Kazakhstan for invention No. 33543 dated 19.03.2019.
- Berezin V.E., Bogoyavlensky A.P., Aleksyuk P.G., Zaitseva I.A., Sadanov A.K. A method for obtaining an immunostimulator based on a nanocomplex of lipids and saponins from the plant mylnyanka officinalis (Saponaria officinalis). Patent of the Republic of Kazakhstan for invention No. 33392 dated 16.01.2019.
- Aleksyuk P.G., Turmagambetova A.S., Bogoyavlensky A.P., Aleksyuk M.S., Berezin V.E. An immunostimulating agent based on purified biologically active compounds of plant origin. Patent of the Republic of Kazakhstan for invention No. 34249 dated 28.01.2020.
- Bogoyavlensky A.P., Turmagambetova A.S., Berezin V.E., Aleksyuk M.S., Aleksyuk P.G. Antiviral composite agent of plant origin. Patent of the Republic of Kazakhstan for invention No. 34248 dated 20.02.2020.
- Turmagambetova A.S., Bogoyavlensky A.P., Berezin V.E., Aleksyuk P.G., Aleksyuk M.S. The use of patuletin (3,5,7,3*,4*- pentaoxy-6-methoxyflavonol) as an antiviral agent against various strains of influenza virus. Patent of the Republic of Kazakhstan for invention No. 34328 dated 03/16/2020.
