Laboratory of Microbial preparations
COMPOSITION OF THE LABORATORY
- Gavrilova N.N. - Chief Researcher, Doctor of Biological Sciences, Professor, laureate of the State Prize of the Republic of Kazakhstan;
- Ratnikova I.A. - Chief Researcher, Doctor of Biological Sciences, Associate Professor, laureate of the State Prize of the Republic of Kazakhstan;
- Orazymbet S.E. – Acting Head of the Laboratory, Deputy Director for Production and Commercialization of Industrial Microbiology LLP, Candidate of Biological Sciences;
- Hvorostov S.A. - Chief Engineer;
- Kosheleva L.A. - Researcher;
- Kaptagai R.Zh. - researcher;
- Belikova O.A. - Researcher;
- Dzhailauova S.B. – Junior researcher;
- A. Junisbekov - Junior Researcher;
- Soltanshcharip E. – laboratory assistant.
- By the Decree of the President of the Republic of Kazakhstan dated November 17, 2011 No. 176, the State Prize of the Republic of Kazakhstan in the field of science and technology was awarded for a series of works on the topic: "Technology of creation and organization of production of biological products "Kazbiosil", "Rizovit-AKS", "Bakoil-KZ" for agriculture and environmental protection;
- Industry Leader 2014.
- The technology of production of preparations of the Bakoil-KZ, Rizovit-AKS, Kazbiosil series has been developed. Developed and approved: pharmacopoeia article (FS RK–535-2003) for the therapeutic and prophylactic drug "Plantafermin"; organization standards for preparations: "Biologically active food additives "Biogarant" based on lactic acid bacteria (dry)" ST RGP 061040002445-02-2011, "Biologically active food additives "Biogarant" based on lactic acid bacteria (liquid)" ST RGP 061040002445-01-2011, "Kazbiosil" ST 81120-1910-GP-08-2011, "Rizovit-AKS" ST81120-1910-GP-10-2012, "Bakoil-KZ" ST 81120-1910-GP-09-2012.
- To date, the preparations "Kazbiosil", "Rizovit-AKS", "Bakoil-KZ", "Polylactovit" and "Bentobak" are being produced on a large scale.
- The laboratory has received 13 copyright certificates, 25 patents and pre-patents, published more than 350 scientific papers, 1 monograph, compiled more than 30 documents on the production and use of drugs.
- Creation and study of complex microbial preparations based on lactic acid, propionic acid and bifidobacteria using prebiotics and extracts of medicinal plants.
- Search and study of new medicinal forms of biological products.
- Development of new microbial preparations for veterinary, medicine, agriculture and food industry.
- Development of technology and organization of pilot production of preparations of microbial origin developed at the Institute.
- Search and study of new medicinal forms of biological products.
- Development of new microbial preparations for veterinary, medicine, agriculture and food industry.
- Development of technology and organization of pilot production of preparations of microbial origin developed at the Institute.
1. No. AR 05132462 "Development of scientific principles for the use of probiotics and medicinal plants in the complex therapy of tuberculosis".
2. No. 0156-18-GC "Organization of production of a therapeutic and prophylactic probiotic of a wide spectrum of antimicrobial action for farm animals and birds"
2. No. 0156-18-GC "Organization of production of a therapeutic and prophylactic probiotic of a wide spectrum of antimicrobial action for farm animals and birds"
- Advanced training of specialists in the isolation of microorganisms from various natural sources, the study of their morphological, physiological and biochemical characteristics and biological activity.
- Determination of the spectrum of antimicrobial activity of various drugs and chemical compounds.
- Microbiological analysis of soils and their biological activity.
- Freeze-drying of biological products.
- Development of technology for the production of microbial preparations for various purposes.
- Development of various microbiological preparations in liquid, pasty and dry form.
- Determination of the spectrum of antimicrobial activity of various drugs and chemical compounds.
- Microbiological analysis of soils and their biological activity.
- Freeze-drying of biological products.
- Development of technology for the production of microbial preparations for various purposes.
- Development of various microbiological preparations in liquid, pasty and dry form.
- Ratnikova I.A., Gavrilova N.N., Bayakyshova K., Turlybayeva Z.Zh., Utegenova N.M., Kosheleva L.A. Investigation of the ability of lactic acid bacteria adapted to low pH and bile values to grow on media with fructooligosaccharides // Materials of the conference "Contribution of microbiology and virology to modern bioindustry" - Almaty, 2016. - pp. 49-55.
- Gavrilova N.N., Ratnikova I.A., Sadanov A.K., Bayakyshova K. Optimization of conditions of production of an antitumoral probiotic // Theses of the 6th International Scientific Conference "European Applied Sciences: challenges and solutions", Stuttgart. – 2016. - P. 3-5.
- Tanbayeva G, Murzabekov Z., Tagaev O., Ratnikova I., Gavrilova N., Barachov B., Narbayeva D. The results of the Application of a probiotic as a therapeutic and prophylactic agent in the early formof the mastitis in fairy cows // Biosciences Biotechlology Research Asia. – 2016. - 13(3). – P. 1579-1584.
- Ratnikova I.A., Gavrilova N.N., Sadanov A.K., Bayakyshova K.,Turlybayeva Z.Zh. Study of the effect of probiotic microorganisms and their associations on the cellular immunity and morphological composition of the blood of rabbits // Theses of International Scientific Conference on Probiotics and Prebiotics - IPC2015.- Budapest, Hungary, 2016– p. 113-114.
- Ratnikova I.A., Gavrilova N.N., Bayakyshova K., Turlybayeva Z.Zh., Utegenova N.M., Kosheleva L.A., Chugai O.G. Anti-radiation and reactivating activity of a probiotic used for the prevention and treatment of mixed intestinal infections in farm animals and birds // Izvestiya NAS RK, ser. biol. – 2016.- No.3.- pp. 40-46. IF – 0,039
- Ratnikova I.A., Gavrilova N.N., Sagidoldina Z.E. Creation of a probiotic of a broad spectrum of activity on the basis of lactic acid and propioni acid bacteria for veterinary medicine // Izvestiya NAS RK, ser. biol. and med. – 2019. – No. 5. – C. 17-23. (IF-0.035)
- Ratnikova I., Gavrilova N., Sadanov A., Bayakyshova K., Melnikov V., Chugai O. Antimicrobial activity of lactic acid bacteria metabolites // Abstr. of 12th International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health, IPC. – Budapest, Hungary, 2018. – P. – 111.
- Ratnikova I.A., Sadanov A.K., Gavrilova N.N., Kosheleva L.A., Orazymbet S.E., Chugai O.G. Selection of medicinal plants suppressing the growth of mycobacteria // Colloquium-journal. – 2019. – No. 36. – pp. 13-16. (RSCI)
- Ratnikova I.A., Gavrilova N.N., Sadanov A.K., Orazymbet S.E., Belikova O.A. The effect of the lactic acid bacteria culturing conditions on their antagonistic activity to pathogens of tuberculosis // La Prensa Medica Argentina. – 2019. – Vol. 105, N 4. – P. 192-196. (IF-0,12)
- Ratnikova I.A., Gavrilova N.N., Sagidoldina Z.E. Creation of a probiotic of a broad spectrum of activity on the basis of lactic acid and propioni acid bacteria for veterinary medicine // Izvestiya NAS RK, ser. biol. and med. – 2019. – No. 5. – C. 17-23. (IF-0.035)
- Ratnikova I., Gavrilova N., Sadanov A., Bayakyshova K., Melnikov V., Chugai O. Antimicrobial activity of lactic acid bacteria metabolites // Abstr. of 12th International Scientific Conference on Probiotics, Prebiotics, Gut Microbiota and Health, IPC. – Budapest, Hungary, 2018. – P. – 111.
- Ratnikova I.A., Sadanov A.K., Gavrilova N.N., Kosheleva L.A., Orazymbet S.E., Chugai O.G. Selection of medicinal plants that inhibit the growth of mycobacteria // Colloquium-journal. – 2019. – No. 36. – pp. 13-16. (RSCI)
- Ratnikova I.A., Gavrilova N.N., Sadanov A.K., Orazymbet S.E., Belikova O.A. The effect of the lactic acid bacteria culturing conditions on their antagonistic activity to pathogens of tuberculosis // La Prensa Medica Argentina. – 2019. – Vol. 105, N 4. – P. 192-196. (IF-0,12).
- The drug "Bakoil-KZ" for cleaning the soil from oil and petroleum products. Innovation patent No. 24879 dated 15.11.2011. (A.K. Sadanov, S.A. Aitkeldieva, N.N. Gavrilova, I.A. Ratnikova).
- A method for increasing antimicrobial activity in probiotic microorganisms. Conclusion on the grant of a patent for an invention. Application No. 2014/1769.1 dated 11/28/2014. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev).
- A method for obtaining liquid probiotics. Conclusion on the grant of a patent for an invention. Application No. 2014/1264.1 dated 30.09.2014. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A method for obtaining the bacterial preparation "Phytobacyrin-D" for fertilizing the clover. Innovation Patent No. 29405. Publ. 25.12.2014, byul. No. 12. (A.K. Sadanov, I.E. Smirnova, N.N. Gavrilova, I.A. Ratnikova).
- A method for obtaining liquid probiotics to increase their survival rate when used. Conclusion on the grant of a patent for an invention. Application No. 2014/1770.1 dated 11/28/2014. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, N.S. Bekturganov).
- The method of obtaining a feed additive Bentobak. Conclusion on the grant of a patent for an invention. Application No. 2014/1773.1 dated 11/28/2014. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev).
- A method for obtaining a pasty starter culture "Kazbiosil" for silage of plant feeds. Conclusion on the grant of a patent for an invention. Application No. 2014/1771.1 dated 11/28/2014. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev).
- Method of preparation of the drug plantafermin. Conclusion on the grant of a patent for an invention. Application No. 2014/1772.1 dated 11/28/2014. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, N.S. Bekturganov).
- A means for the prevention and complex therapy of oncological diseases. Innovation patent No. 28669. Publ.15.04.2014, byul. No. 4. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A strain of Lactobacillus cellobiosus 35/1 bacteria intended for the production of therapeutic and prophylactic drugs. Conclusion on the grant of a patent for an invention. Application No. 2014/1788.1 dated 02.12.2014. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A strain of Lactobacillus cellobiosus 36 bacteria intended for the production of therapeutic and prophylactic drugs. Conclusion on the grant of a patent for an invention. Application No. 2014/1789.1 dated 02.12.2014. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A strain of Lactobacillus fermentum 30 bacteria intended for the production of therapeutic and prophylactic drugs. Conclusion on the grant of a patent for an invention. Application No. 2014/1787.1 dated 02.12.2014. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A strain of Lactobacillus plantarium 19 bacteria intended for inclusion in the composition of therapeutic and prophylactic drugs against gastrointestinal diseases. Conclusion on the grant of a patent for an invention. Application No. 2014/1788.1 dated 02.12.2014. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A strain of Lactobacillus plantarium 48 bacteria intended for inclusion in microbial preparations against gastrointestinal diseases. Conclusion on the grant of a patent for an invention. Application No. 2014/1785.1 dated 02.12.2014. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A strain of the bacterium Micrococcus roseus 34-2 for cleaning the soil from oil and petroleum products. Patent for invention No. 30870 (application No. 2014/1270.1 dated 30.09.2014). (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev).
- A strain of bacteria Micrococcus roseus 49-7 for cleaning the soil from oil and petroleum products. Conclusion on the grant of a patent for an invention. Application No. 2014/1271.1 dated 30.09.2014. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev).
- A method for obtaining a paste-like preparation of nitrogen-fixing bacteria under soy. RK Patent No. 30491. Publ. 15.10.2015, byul. No. 10. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev).
- A method for obtaining a paste-like preparation of nitrogen-fixing bacteria for alfalfa. RK Patent No. 30492. Publ. 15.10.2015, byul. No. 10. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev).
- A method for obtaining a paste-like preparation of nitrogen-fixing bacteria under peas. Patent No. 30598. Publ. 16.11.2015, byul. No. 11. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev).
- A method for obtaining a paste-like preparation of nitrogen-fixing bacteria under chickpeas. Patent No. 30597. Publ. 16.11.2015, byul. No. 11. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev).
- A method for obtaining the drug "Bakoil-KZ" for cleaning the soil from oil and petroleum products. Patent for invention No. 30869. 12/25/15, byul. No. 12. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev).
- A method for obtaining a drug against mixed intestinal infection. Patent for invention No. 30874 25.12.2015, byul. No. 12. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, N.S. Bekturganov).
- A strain of Lactobacillus brevis B-3/75 bacteria intended for inclusion in the composition of therapeutic and prophylactic drugs against gastrointestinal diseases. Patent No. 30601. Publ. 16.11.2015, byul. No. 11. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A strain of Lactobacillus casei 173A bacteria intended for inclusion in the composition of therapeutic and prophylactic drugs against pasteurellosis. Patent No. 30604. Publ. 16.11.2015, byul. No. 11. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev, N.S. Bekturganov).
- A strain of bacteria Lactobacillus cellobiosus 34/16, intended for the production of therapeutic and prophylactic drugs and products. Patent No. 30600. Publ.16.11.2015, byul. No. 11. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A strain of Lactobacillus cellobiosus 35/23 bacteria intended for the production of therapeutic and prophylactic drugs and products. Patent No. 30701. Publ. 15.12.2015, byul. No. 12. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A strain of bacteria Lactobacillus fermentum 29/7, intended for the production of therapeutic and prophylactic drugs and products. Patent No. 30599 Publ. 16.11.2015, byul. No. 11. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A strain of Lactobacillus plantarum bacteria 14D/A-17, intended for inclusion in microbial preparations against purulent infections and gastrointestinal diseases. Patent No. 30603. Publ. 16.11.2015, byul. No. 11. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev).
- A strain of Lactobacillus salivarius bacteria 8D/AK-5, intended for inclusion in the composition of microbial preparations against brucellosis. Patent No. 30602. Publ. 16.11.2015, byul. No. 11. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, N.S. Bekturganov).
- A strain of the bacterium Lactobacillus fermentum 27/Ap-5, intended for inclusion in the composition of microbial preparations against gastrointestinal diseases. Patent for invention No. 30856 25.12.2015, byul. No. 12. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, N.S. Bekturganov).
- A strain of Lactobacillus plantarum 2b/2 bacteria intended for inclusion in the composition of therapeutic and prophylactic drugs against gastrointestinal diseases. Patent for invention No. 30868. 12/25/2015, byul. No. 12. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A strain of nodule bacteria Rhizobium meliloti (Sinorhizobium meliloti) L-5-1, L-5-1/24, used to produce a bacterial preparation for alfalfa. Patent No. 30700. Publ. 15.12.2015, byul. No. 12. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, E.Zh. Shorabaev, N.S. Bekturganov).
- A strain of nodule bacteria Bradyrhizobium japonicum AKS-18, used for the production of bacterial fertilizer for soybeans. RK Patent No. 30493. Publ. 15.10.2015, byul. No. 10. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova, N.S. Bekturganov, E.Zh. Shorabaev).
- A strain of Lactobacillus Casei 173A bacteria intended for inclusion in the composition of therapeutic and prophylactic drugs against pasteurellosis. Patent for invention No. 30604, 16.11.2015, byul. No. 11. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Shorabaev E.Zh., Bekturganov N.S.).
- A strain of Lactobacillus Plantarum bacteria 14D/A-17, intended for inclusion in microbial preparations against purulent infections and gastrointestinal diseases. Patent for invention No. 30603, 11/16/2015, byul. No. 11. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Shorabaev E.Zh.).
- Strain of bacteria Lactobacillus salivarius 8D/AK-5, intended for inclusion in the composition of microbial preparations against brucellosis. Patent for invention No. 30602, 16.11.2015, byul. No. 11. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Bekturganov N.S.).
- A strain of Lactobacillus brevis B-3/75 bacteria intended for inclusion in the composition of therapeutic and prophylactic drugs against gastrointestinal diseases. Patent for invention No. 30601, 11/16/2015, byul. No. 11. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- Strain of bacteria Lactobacillus cellobiosus 34/16, intended for the production of therapeutic and prophylactic drugs and products. Patent for invention No. 30600, 16.11.2015, byul. No. 11. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- A strain of bacteria Lactobacillus fermentum 29/7, intended for the production of therapeutic and prophylactic drugs and products. Patent for invention No. 30599, 11/16/2015, byul. No. 11. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- Method for obtaining a paste-like preparation of nitrogen-fixing bacteria for peas. Patent for invention No. 30598, 16.11.2015, byul. No. 11. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Shorabaev E.Zh.).
- A method for obtaining a paste-like preparation of nitrogen-fixing bacteria under chickpeas. Patent for invention No. 30597, 11/16/2015, byul. No. 11. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Shorabaev E.Zh.).
- Strain of nodule bacteria Rhizobium Meliloti (Sinorhizobium Meliloti) L5-1/24, used for the production of bacterial fertilizer for alfalfa. Patent for invention No. 30700, 15.12.2015, byul. No. 12. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Shorabaev E.Zh., Bekturganov N.S.).
- A strain of Lactobacillus cellobiosus 35/23 bacteria intended for the production of therapeutic and prophylactic drugs. Patent for invention No. 30701, 12/15/2015, byul. No. 12 (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- A strain of Lactobacillus plantarum 2b/2 bacteria intended for inclusion in the composition of therapeutic and prophylactic drugs against gastrointestinal diseases. Patent for invention No. 30868 25.12.2015 byul.No. 12. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- Method of obtaining the "Bakoil-KZ" praparate for soil purification from oil and petroleum products. Patent for invention No. 30869, 25.12.2015 byul. No. 12. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Shorabaev E.Zh.).
- A method for increasing antimicrobial activity in probiotic microorganisms. Patent for invention No. 31082, 04/15/2016, byul. No. 4. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Shorabaev E.Zh.).
- A method for obtaining liquid probiotics to increase their survival rate when used. Patent for invention No. 31081, 04/15/2016, byul. No. 4. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Bekturganov N.S.).
- Method for obtaining liquid probiotics. Patent for invention No. 31083, 04/15/2016, byul. No. 4. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- The method of obtaining a feed additive Bentobak. Patent for invention No. 31262, 06/15/2016, byul. No. 6. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Shorabaev E.Zh.).
- Method for obtaining pasty starter culture "Kazbiosil" for silage of plant feeds. Patent for invention No. 31079, 04/15/2016, byul. No. 4. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Shorabaev E.Zh.).
- Method for obtaining the drug plantafermin. Patent for invention No. 31269, 06/15/2016, byul. No. 6. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Bekturganov N.S.).
- A method for obtaining a drug against mixed intestinal infection. Patent for invention No. 30874, 25.12.2015 byul.No. 12. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Bekturganov N.S.).
- Method of application of the antibiotic doxorubicin in the complex therapy of oncological diseases. Patent for invention No. 31975, Application No. 2015/1111.1 dated 07.10.2015. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- Method of silage of plant feeds. Patent for invention No. 31961, Application No. 2015/0503.1 dated 07.04.2015. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- A means of preventing mastitis in lactating cows. Patent application of the Republic of Kazakhstan, register. No. 2016/0512.1. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- A strain of Lactobacillus cellobiosus 35/1 bacteria intended for the production of therapeutic and prophylactic drugs. Patent for invention No. 31465, 1.08.2016 byul. No. 10. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- 908. Strain of bacteria Lactobacillus cellobiosus 36, intended for the production of therapeutic and prophylactic drugs. Patent for invention No. 31466, 31.08.2016 byul. No. 10. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- A strain of the bacterium Lactobacillus fermentum 27/Ap-5, intended for inclusion in the composition of microbial preparations against gastrointestinal diseases. Patent for invention No. 30856. 25.12.2015 byul.No. 12. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Bekturganov N.S.). A
- strain of Lactobacillus fermentum 30 bacteria intended for the production of therapeutic and prophylactic drugs. Patent for invention No. 31274, 06/15/2016, byul. No. 6. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- A strain of Lactobacillus Plantarium 19 bacteria intended for inclusion in the composition of therapeutic and prophylactic drugs against gastrointestinal diseases. Patent for invention No. 31464, 08/31/2016. byul. No. 10. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- A strain of Lactobacillus Plantarium 48 bacteria intended for inclusion in microbial preparations against gastrointestinal diseases. Patent for invention No. 31196, 05/15/2016, byul. No. 5. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- A strain of the bacterium Micrococcus roseus 34-2 for cleaning the soil from oil and petroleum products. Patent for invention No. 30870 (application No. 2014/1270.1 dated 30.09.2014). (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Shorabaev E.Zh.).
- Strain of bacteria Micrococcus roseus 49-7 for soil purification from oil and petroleum products. Patent for invention No. 31091, 04/15/2016, byul. No. 4. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A., Shorabaev E.Zh.).
- Method of bioremediation of oil-contaminated soils (variants). Patent for invention No. 32292, 15.08.2017, byul. No. 15. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- A method for obtaining a bacterial preparation of complex action against leaf-gnawing insects, stem nematodes and pathogens of root diseases of plants. Patent for invention No. 29697, 31.08.2017, byul. No. 16. (A.K. Sadanov, Aitkeldieva S.A., Shemshura O.N., Gavrilova N.N., Ratnikova I.A., Bekmakhanova N.E.).
- Method of preparation of the drug Polylactovit. Application for a patent of the Republic of Kazakhstan. – register. No. 2017/0483.1. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
- A means for the prevention and complex therapy of oncological diseases. Patent for invention No. 32290, 15.08.2017, byul. No. 15. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- Strain of bacteria Lactobacillus cellobiosus 20/2, intended for the production of therapeutic and prophylactic drugs. Application for a patent of the Republic of Kazakhstan. - register No. 2017/0484.1. (A.K. Sadanov, Ratnikova I.A., Gavrilova N.N.).
- A means for the prevention of mastitis in lactating cows. Patent for invention No. 32914, 29.06.2018, byul. No. 24. (A.K. Sadanov, Gavrilova N.N., Ratnikova I.A.).
- A method for obtaining a phosphatemobilizing bacterial preparation. Patent No. 33394 RK, (21) 2016/0630.1, (22) 14.07.2016, Date of issue: 16.01.2019. (A.K. Sadanov, I.E. Smirnova, N.N. Gavrilova, I.A. Ratnikova).
- Methods of obtaining a phosphatemobilizing bacterial preparation. Author's certificate No. 106874. (A.K. Sadanov, I.E. Smirnova, N.N. Gavrilova, I.A. Ratnikova).
- A strain of Lactobacillus casei 173a bacteria intended for inclusion in the composition of a probiotic for the complex therapy of tuberculosis. The decision to grant a patent for an invention Register. No. 2019/0771.1. (A.K. Sadanov, I.A. Ratnikova, N.N. Gavrilova).
- A strain of Lactobacillus plantarum 48 bacteria intended for inclusion in microbial preparations against brucellosis. The decision to grant a patent for an invention Register. No. 2019/0581.1. (A.K. Sadanov, N.N. Gavrilova, I.A. Ratnikova).
